Tag: 上海新鼎会到底多荤

  • Bacterial blockade

    first_imgFor decades, doctors have understood that microbes in the human gut can influence how certain drugs work in the body — by either activating or inactivating specific compounds — but questions have remained about exactly how the process works.Harvard scientists are now beginning to provide those answers.In a paper published July 19 in Science, Peter Turnbaugh, a Bauer Fellow at the Center for Systems Biology in the Faculty of Arts and Sciences (FAS), and Henry Haiser, a postdoctoral fellow, identify a pair of genes that appear to be responsible for allowing a specific strain of bacteria to break down a widely prescribed cardiac drug into an inactive compound, as well as a possible way to turn the process off.“The traditional view of microbes in the gut relates to how they influence the digestion of our diet,” Turnbaugh said. “But we also know that there are over 40 different drugs that can be influenced by gut microbes. What’s really interesting is that although this has been known for decades, we still don’t really understand which microbes are involved or how they might be processing these compounds.”To answer those questions, Turnbaugh and his colleagues chose to focus on digoxin, one of the oldest known cardiac glycosides. The medicine is typically prescribed to treat heart failure and cardiac arrhythmia.“It’s one of the few drugs that, if you look in a pharmacology textbook, it will say that it’s inactivated by gut microbes,” Turnbaugh said. “John Lindenbaum’s group at Columbia showed that in the 1980s. They found that a single bacterial species, Eggerthella lenta, was responsible.”Researchers in the earlier study also tried — but failed — to show that testing bacterial samples from a person’s gut could be used to predict whether the drug might be inactivated.“To some degree the research was stalled there for a number of years, and the findings in our paper help to explain why,” Turnbaugh said. “Originally, it was hoped that we would simply be able to measure the amount of E. lenta in a person’s gut and predict whether the drug would be inactivated, but it’s more complicated than that.”Beginning with lab-grown samples of E. lenta — some cultured in the presence of digoxin, some in its absence — Turnbaugh and Haiser tested to see if certain genes were activated by the presence of the drug.“We identified two genes that were expressed at very low levels in the absence of the drug, but when you add the drug to the cultures … they come on really strong,” Turnbaugh said. “What’s encouraging about these two genes is that they both express what are called cytochromes — enzymes that are likely capable of converting digoxin to its inactive form.”Though he warned that more genetic testing is needed before the results are definitive, Turnbaugh said other experiments support these initial findings.The researchers found only a single strain of E. lenta — the only one that contained the two genes they had earlier identified — was capable of inactivating digoxin. In tests using human samples, bacterial communities that were able to inactivate the drug also showed high levels of these genes“We were able to confirm that simply looking for the presence of E. lenta is not enough to predict which microbial communities inactivate digoxin,” Turnbaugh said. “We found detectable E. lenta colonization in all the human fecal samples we analyzed. But by testing the abundance of the identified genes we were able to reliably predict whether or not a given microbial community could metabolize the drug.”In addition to being able to predict whether a given microbial community would inactivate the drug, Turnbaugh and colleagues identified a possible way to halt the process.“It was previously shown that in the lab E. lenta grows on the amino acid arginine and that as you supply more and more arginine, you inhibit digoxin inactivation,” he said.Tests conducted with mice showed that animals fed a diet high in protein, and thereby arginine, had higher levels of the drug in their blood than mice fed a zero-protein diet.“We think that this could potentially be a way to tune microbial drug metabolism in the gut,” Turnbaugh said. “Our findings really emphasize the need to see if we can predict or prevent microbial drug inactivation in cardiac patients. If successful, it may be possible someday to recommend a certain diet, or to co-administer the drug with an inhibitor like arginine, ensuring a more reliable dosage.”last_img read more

  • Investigators Allegedly Find Drugs, Cash, And A Loaded Handgun During Raid

    first_imgJamestown Police say Luis Martinez, 48, Sammy McKeithan, 38, Edwin Rosario, 31, and Shelia Mendez, 36, were taken into custody after SWAT kicked down the door at 64 Water St., Apt. 1 on Friday evening.Inside the apartment, investigators allegedly found 14 ounces of methamphetamine, one ounce of cocaine, 3.4 grams of crack cocaine, drug paraphernalia and $3,500 in crash.Additionally, police said a loaded 9mm handgun stolen from a Jamestown home in 2018 was recovered. Martinez, McKeithan, and Rosario are all charged with varying degrees of criminal possession of a controlled substance. Police said charges are pending against Mendez.The four were taken to Jamestown City Jail pending arraignment in the case. Sammy McKeithan Luis Martinez Edwin Rosariocenter_img Image by Jamestown Police.JAMESTOWN – Investigators with the Jamestown Metro Drug Task Force say they allegedly recovered drugs, cash and a loaded handgun after executing a search warrant at a Water Street Apartment last week. Share:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to email this to a friend (Opens in new window)last_img read more

  • The Masters: Watch Amen Corner coverage via Sky Sports’ live video stream | Golf News

    first_img Get the best prices and book a round at one of 1,700 courses across the UK & Ireland Watch the world’s top golfers tackle Augusta National’s Amen Corner at The Masters via Sky Sports’ live stream. Featured Groups available on Sky Sports The Masters, with extra coverage via the red button. By Sky Sports GolfLast Updated: 13/11/20 11:34pm – Advertisement – The Masters latest headlines Latest news and interviews from the 84th Masters at Augusta National. Tiger Woods returns as defending champion at The Masters Tiger Woods returns as defending champion at The MastersTiger Woods returns as defending champion at The Masters Tiger Woods returns as defending champion at The Masters The 12th, where Jordan Spieth saw his hopes a second consecutive green jacket vanish after a quadruple bogey in 2016, is a demanding 155-yard par three over Rae’s Creek and one of the most iconic holes in the sport. Streaming from Amen Corner is available from approximately 12.30pm UK time on Saturday via the red button on Sky Sports Golf, the new Sky Sports Golf YouTube channel or by clicking the video at the top of the page!Watch the Masters throughout the week live on Sky Sports The Masters. Click here to upgrade to Sky Sports for just £10 a month. Watch a live stream of Amen Corner here Watch a live stream of Amen Corner here Augusta National’s Amen Corner is one of the most sacred places in golf and you can see all the world’s best players tackle the famous stretch, for free, via the new Sky Sports Golf YouTube channel.The Masters is the final men’s major of a condensed 2020 schedule, with all four rounds exclusively live on Sky Sports The Masters and a host of extra feeds and coverage available via the red button.Amen Corner will provide a compelling challenge for all of the 92-man field, with the three-hole stretch instantly recognisable to golf fans and part of plenty of iconic moments in Masters history. The Masters – Live November 12, 2020, 6:00pmLive on – Advertisement – The 510-yard par five 13th is a sweeping dogleg, and an accurate tee shot offers a chance to reach the raised green in two, with Bryson DeChambeau among those looking to take advantage of his distance on that hole. Get Sky Sports Golf for just £10 a month All four days of The Masters exclusively live. Get our £10 golf offer. Find out more here. The stretch begins with a 505-yard par four at the 11th, with the green guarded by a pond to the left and a bunker positioned strategically to the right centre. – Advertisement – – Advertisement –last_img read more

  • Fuel Truck Overturns at PBIA

    first_imgThe driver was not injured, and there was no leak from the main tank.Aircraft activity was temporarily redirected away from the area as a precaution. Fire Rescue officials responded to Palm Beach International Airport on Saturday, after receiving reports that a fuel truck had overturned.Crews offloaded fuel from the tank before a wrecker righted the truck.last_img

  • Mithali Raj hopes India can seal direct berth at 2021 Women’s World Cup

    first_imgThe Indian women’s ODI team captain Mithali Raj feels the side’s confidence has gone up following the 2-1 series win over New Zealand and it is now aiming to avoid qualifiers for the 2021 World Cup by staying in top four of the ICC table.India are currently placed third in the table after winning the three-match away series against New Zealand 2-1 recently. They are scheduled to host England in the next assignment of the championship cycle later this month.”The last time we played the Qualifiers, but this time we want to have direct qualification for 2021. With series against England and the Windies coming up, we will definitely look to get maximum points,” Mithali was quoted as saying in a release from the International Cricket Council.”…we did not have too many players who had the experience of the conditions with only Jhulan (Goswami) and me having toured here before. So winning two games here has given us a lot of confidence,” she said.”Losing the third game, we have come down to number three in the rankings table but I am happy that India are in the top four,” she added.The coming month will see focus on the championship with two more series featuring teams in the upper tiers of the points table — Australia host New Zealand and India host England in series starting February 22.These teams are the frontrunners to make the cut since New Zealand and four other top teams get direct entries to the premier event two years from now.advertisementNew Zealand captain Amy Satterthwaite said her side has learnt its lessons from the debacle against India.”We have our first real winter at home in 3-4 years coming up which gives us a great opportunity to develop our skill sets, so playing a quality side like India helps to highlight those areas both individually and as a team,” she said.”The points table is a hard one to read into much because some teams haven’t played as many games as us. Sitting in second is a great place to be, but as other teams play more games, that may change,” she added.Also Read | I have to bat till 20 overs to avoid another collapse: Smriti MandhanaAlso Read | We were outplayed in all departments: Rohit Sharma after India’s worst T20I defeatAlso See:last_img read more

  • BOND REDUCED FOR FORMER LAWTON CITY CLERK

    first_imgBond has been reduced for the former city clerk of Lawton, Iowa who is charged in Dakota County in a child sex case.A judge reduced bond Wednesday for 61-year-old Douglas Furlich from $250-thousand to 10 per cent cash of $100,000 dollars.Furlich has pleaded not guilty to a felony count of child enticement by use of an electronic communications device.The Nebraska State Patrol says Furlich posted an ad online saying he was “looking for a younger guy.”An undercover officer responded, pretending to be a 15-year-old boy.The Lawton City Council later fired Furlich after his arrest.A pre-trial hearing for Furlich was postponed until September 21st at his attorney’s request.last_img read more