Tag: 上海夜网WZ

  • South Florida union leader opposes plan to end TPS for Haitians…

    first_imgResponding to a recommendation made last week by the United States Citizenship and Immigration Service (USCIS) for the Trump administration to end Temporary Protected Status (TPS) for Haitians by next January, Helene O’Brien, Florida Director of the national worker’s union, 32BJ SEIU has referred to any such plan as unconscionable.In a statement O’Brien said, “The USCIS’ recommendation to end Temporary Protected Status (TPS) for Haitians is unconscionable and oblivious to the dire conditions that exist in Haiti today.”O’Brien argues Haiti is still reeling from multiple disasters, including the 2010 earthquake that left tens of thousands homeless; a cholera epidemic; and Hurricane Mathew, a category 4 hurricane that cost Haiti $2.7 billion and left half a million children without safe drinking water.The union leader also said ending TPS would further destabilize Haiti and have negative consequences on aspects of the US economy as Haitian TPS holders contribute $280 million a year to the US’ GDP.  Some of these Haitians are small business owners and others are an integral part of the US companies they work for. To support this argument, she claimed local economies in Miami, New York, or Boston, where there are large Haitian communities, and with several Haitian own businesses would be negatively impacted.“We strongly urge DHS Secretary Kelly to reject the USCIS’ recommendation and extend TPS to thousands of vulnerable Haitians living in and contributing to this country. Doing so would avert a humanitarian disaster and reflect the US’ tradition of protecting people from unsafe conditions outside of their control,” O’Brien concluded.TPS was granted to Haitian refugees by the Obama administration following the 2010 earthquake. The measure allowed these Haitians to live and work in the US legally. Last year the administration signaled it would commence cancelling the benefit and return refugees based on the administration’s assessment that conditions in Haiti had improved sufficiently to warrant their return.However. the repatriation plan was disrupted, and eventually placed on hold, because of another natural disaster, Hurricane Matthew, in Haiti last summer.Several South Florida political, business, Haitian and other community leaders have appealed to the Trump administration  not to cancel TPS for Haitian refugees. A bipartisan coalition of elected officials, including Senator Marco Rubio (R) and Representatives Ileana Ros-Lehtinen (R) and Frederica Wilson (D) have publicly stated their support of TPS.last_img read more

  • Gene regulator associated with protein pileup in exfoliation glaucoma

    first_img Source:https://www.augusta.edu/mcg/ Jul 19 2018In exfoliation glaucoma, a protein dandruff clogs the outflow pathway for the fluid in our eyes.Scientists have evidence that variants of the same gene that enables us to make connective tissue by crosslinking proteins is associated with this unusual glaucoma.Now they are looking in human eye tissue at a long piece of RNA that helps control expression of that LOXL1 gene with the idea that it may be a culprit in the destructive pileup of LOXL1 protein inside the eye.A new, $440,000 grant from the National Eye Institute is helping Dr. Yutao Liu and his colleagues further explore the relationship between the gene and this long, noncoding RNA dubbed lncLOXL1.A long-term goal is finding better treatment targets for this glaucoma, which is generally more aggressive and difficult to treat than its more common counterpart, primary open angle glaucoma, says Liu, vision scientist and human geneticist in the Department of Cellular Biology and Anatomy at the Medical College of Georgia at Augusta University.”Variants of this gene are associated with the disease in every population we have studied worldwide,” Liu says, including Caucasians, blacks in South Africa, the Japanese as well as Southeast Asians in India. They found the expression of LOXL1 consistently elevated early in the disease in every population. Variants are basically a slight difference in the most usual sequence of letters in the DNA.High levels of LOXL1 protein that clog outflow tracts for the eye’s aqueous humor also are a constant in all those patients. Still, there is conflicting laboratory evidence about the role of the suspect gene because neither removing or overexpressing it always results in the classic protein accumulation and high pressure inside the eye, at least in lab animals. So Liu and his team are also now looking at lncLOXL1, which regulates the gene’s expression.So far they have seen the expression level of the gene and lncLOXL1 correlate in both gene variations the scientists have seen in the human populations they have studied. They also have seen that as disease progresses, the gene expression goes down even as the protein piles up, typically at about age 60.One of the many things they want to know now is what happens to the lncLOXL1 expression in disease. Does its expression also go down when disease becomes symptomatic, or does its parallel expression with the gene part ways at that point?Knowing that will help determine whether it might one day need to be turned up or down to help patients, Liu says.They also are further refining exactly what lncLOXL1 does and how it does it by looking at what genes/proteins are affected when it’s knocked out and overexpressed.”We are looking at what happens to expression of both the LOXL1 gene and its protein when we remove lncLOXL1 from the equation and when we overexpress it,” Liu says.They are also looking at other factors floating in the eye fluid with disease. Along with way too much protein, there are proinflammatory factors like transforming growth factor beta one, a protein with a wide range of functions from helping cells mature, grow, differentiate and even die, to promoting an inflammatory response; cytokines secreted by immune cells; and hydrogen peroxide, a product of high levels of oxidative stress.Related StoriesMother calls for protein shake regulation after daughter diesNew ‘molecular scaffolding’ could help restore sight loss caused by glaucomaInhibition of p38 protein boosts formation of blood vessels in colon cancerThey want to know if lncLOXL1 needs one or all these factors to do the damage they think it does. If they block these factors, for example, does the destruction still happen? Liu has already seen that treatment of human eye cells with transforming growth factor beta one impacts expression of this long, noncoding RNA. Now he is looking at things like what happens to levels of the LOXL1 protein.They also are looking at the impact of environmental factors like ultraviolet light, since proximity to sunlight, like individuals who live in the mountains of Iceland, is an established risk factor for exfoliation glaucoma.”From what we have seen so far, we don’t think coding changes of this gene have anything to do with the disease, so it must be gene regulation,” Liu says, and that could mean lncLOXL1.A handful of years ago, Liu and colleagues at Duke University did a genetic association study – which looked at genetic risk factors – and found that variants of the gene LOXL1 in the noncoding region were associated with exfoliation glaucoma. The variance was in a sequence of the gene’s DNA called the intron, which helps regulate gene expression, so how much of which proteins get made by the gene rather than actual protein production. Coding regions of genes that make proteins are called exons, and introns are considered non-coding regions.The genetic variants appeared to impact not which proteins got made, but how much got made. With exfoliation glaucoma, it’s definitely too much.In addition to clogging fluid paths, over time the protein pileup appears to nibble away at the endothelial cells that line blood vessels as well as the pericytes, contractile cells that wrap around the endothelial cells and help give blood vessel walls strength and flexibility. The protein also weakens zonules, transparent tendons that help hold the lens of the eye in place.Although inflammation contributes to the destruction in exfoliation glaucoma, the immune system often does not eliminate the dandruff-like flakes congesting fluid flow of the eye. Pressure inside the eye soars and the eyedrops that help the more common open-angle glaucoma by increasing outflow and/or decreasing fluid production don’t work. Surgery to improve outflow often does not work long either.The current studies are primarily using eye tissue from the lens capsule of 20 patients with exfoliation glaucoma as well as 20 patients who needed cataract surgery and are considered the controls. One thing both populations have in common is they are older, which is when cataracts and symptoms of exfoliation glaucoma both tend to surface.Liu notes that not everyone with one of the known gene variants develops exfoliation glaucoma, and that as with many diseases, it’s likely a combination of genes and environment that’s causative.The aqueous humor directly provides nutrition to the eye and the invaluable fluid is normally replaced about every 90 minutes.In recent years, long, noncoding RNAs, which as the name implies are longer than some of their colleagues like microRNA, have been associated with an increasing number of diseases including a wide variety of cancers and cardiovascular disease.last_img read more